Fluorescence PCR · Oncology
Human BCR-ABL Fusion Gene Detection Kit (Fluorescence PCR)
Qualitative detection of BCR-ABL fusion gene p190, p210, and p230 isoforms in human bone marrow samples. Aids in diagnosis and monitoring of chronic myeloid leukemia (CML).
- SKU Code
AENE-GE010A- Approval
- On request
- Product Type
- Assay / Kit
- Status
- Available
Qualitative detection of BCR-ABL fusion gene p190, p210, and p230 isoforms in human bone marrow samples. Aids in diagnosis and monitoring of chronic myeloid leukemia (CML).
| Product type | Assay / Kit |
|---|---|
| Technology platform | Fluorescence PCR |
| Application area | Oncology |
Epidemiology
Chronic myelogenous leukemia (CML) arises from a malignant clonal expansion of hematopoietic stem cells. Over 95% of individuals with CML harbor the Philadelphia chromosome (Ph) in their blood cells. The primary pathogenic mechanism involves formation of the BCR-ABL fusion gene through a reciprocal translocation between the abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) at chromosome 9q34 and the breakpoint cluster region (BCR) gene at 22q11. The resulting fusion protein possesses tyrosine kinase (TK) activity and triggers downstream signaling cascades—including RAS, PI3K, and JAK/STAT pathways—that drive cell proliferation and suppress apoptosis, leading to malignant cell growth and CML development. The BCR-ABL fusion is a key diagnostic marker for CML. Moreover, monitoring changes in its transcript levels serves as a dependable indicator for assessing prognosis and predicting leukemia relapse following therapy.
| SKU code | AENE-GE010A |
|---|---|
| Storage | Liquid: ≤-18℃ In dark |
| Shelf-life | Liquid: 9 months |
| Specimen Type | Bone marrow samples |
| LoD | 1000 Copies/ mL |
| Specificity | There is no cross-reactivity with other fusion genes TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, and PML-RARa |
| Applicable Instruments | Applied Biosystems 7500 Real-Time PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio® 5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler®480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System |
| Approval | On request |
|---|---|
| Documents | Datasheet, IFU, SDS, COA / conformance, origin, and export documents where available |
FAQ
What should be confirmed before quotation?
Sample context, collection method, and extraction workflow should be confirmed before final kit selection.
Which documents can be requested?
Datasheet, IFU, SDS, COA / conformance, origin, insurance, and export documents can be checked where available.
Can the format be adjusted for different workflows?
Liquid or lyophilized format options should be confirmed together with instrument compatibility and shipment requirements.
Inquiry
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