Fluorescence PCR · Oncology
TEL-AML1 Fusion Gene Detection Kit (Fluorescence PCR)
Qualitative detection of the TEL-AML1 fusion gene in human bone marrow specimens by fluorescence PCR. The assay aids in prognosis determination for pediatric patients with B-lineage acute lymphoblastic leukemia (ALL).
- SKU Code
AENE-TM016- Approval
- On request
- Product Type
- Assay / Kit
- Status
- Available
Qualitative detection of the TEL-AML1 fusion gene in human bone marrow specimens by fluorescence PCR. The assay aids in prognosis determination for pediatric patients with B-lineage acute lymphoblastic leukemia (ALL).
| Product type | Assay / Kit |
|---|---|
| Technology platform | Fluorescence PCR |
| Application area | Oncology |
Epidemiology
Among childhood cancers, acute lymphoblastic leukemia (ALL) is the most frequent. The classification of acute leukemia (AL) has evolved from the MIC system (morphology, immunology, cytogenetics) to MICM, which incorporates molecular biology testing. In 1994, the TEL fusion in pediatric B-lineage ALL was attributed to the recurrent translocation t(12;21)(p13;q22). Following the identification of the AML1 fusion gene, the TEL-AML1 fusion is now considered the most reliable prognostic indicator in children with ALL.
Work Flow
The procedure utilizes a commercial kit for total RNA isolation from whole blood.
| SKU code | AENE-TM016 |
|---|---|
| Storage | ≤-18℃ |
| Shelf-life | 9 months |
| Specimen Type | bone marrow sample |
| Ct | ≤40 |
| CV | 5.0% |
| LoD | 1000Copies/mL |
| Specificity | There is no cross-reactivity between the kits and other fusion genes like BCR-ABL, E2A-PBX1, MLL-AF4, AML1-ETO, PML-RARa fusion genes. |
| Applicable Instruments | Applied Biosystems 7500 Real-Time PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler®480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System |
| Approval | On request |
|---|---|
| Documents | Datasheet, IFU, SDS, COA / conformance, origin, and export documents where available |
FAQ
What should be confirmed before quotation?
Sample context, collection method, and extraction workflow should be confirmed before final kit selection.
Which documents can be requested?
Datasheet, IFU, SDS, COA / conformance, origin, insurance, and export documents can be checked where available.
Can the format be adjusted for different workflows?
Liquid or lyophilized format options should be confirmed together with instrument compatibility and shipment requirements.
Inquiry
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